Course Notes & other materials

Week 1: 29 Aug
Week 2: 5 Sept
Week 3: 12 Sept
Week 4: 19 Sept
Week 5: 26 Sept
Week 6: 3 Oct
Week 7: 10 Oct
Week 8: 17 Oct
Week 9: 24 Oct
Week 10: 31 Oct
Week 11: 7 Nov
Week 12: 14 Nov
Week 13: 21 Nov
Week 14: 28 Nov

News & information

Unit 19 updated, 2017
Unit 20 updated, 2017

We'll be in Ed2 N 2301.

April 2014: The Food and Drug Administration has approved Ragwitek, a sublingual treatment for short ragweed pollen–related allergic rhinitis in people aged 18-65 years. This is the first FDA-approved oral therapy for hay fever, and the third oral allergy medication approved by the FDA in less than a month. On April 1, the agency green-lighted Oralair for the treatment of grass pollen-related allergies in persons aged 10-65 years. On April 15, Grastek earned approval as an oral treatment for grass pollen allergy in people aged 5-65 years.

There is a fascinating north-south gradient in apple allergy in Europe. In the north, it's related to birch pollen allergy, and people have Oral Allergy Syndrome but only to fresh, not cooked, apple. There is a cross-reactive antigen between birch pollen and something that's heat-labile in apples. Birch trees stop at the Alps. Below them, apple allergy is related to peach allergy, and the apple antigen survives cooking, so: no apple pie. The southern form is more severe than the northern and can even be anaphylactic. You can read more.

Guinea worm (dracunculiasis) is nearly eradicated, remaining in isolated areas in 4 African countries. This nasty creature must pass through a human host who acquires both a male and a female larva from drinking water. They mate within, and the egg-laying female emerges from the skin a year later. If this step can be eliminated (the Carter Foundation thinks it can) then the worm will be gone, as there is no other host. Good riddance! 2016 update: As Guinea worm nearly disappeared in humans, it has been found to infect dogs! And dogs in many parts of rural Africa aren't pets, so dog control can be complicated, but must be acomplished or the worm will re-establish in humans.

WEEK 10: 1 November

Unit 19: Immunopathology Type I: Allergy/Parasite Immunity (PDF)

Supplemental material (optional): Human endoparasites

Unit 20: Immunopathology Type IV: T Cell-Mediated (PDF)

Supplemental material (optional): M1 and M2 Macrophage Activation (pdf) A brief review of the two opposing macrophage types, kindly written for us by a former IMMU 7630 student who finished his PhD on tumors and their macrophages in 2011.