Course Notes & other materials

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News & information

We're in Ed2 N 2301.

Units 9/10 notes updated, 2017
Supplements checked, 2017

I've made a short video about T-dependent and T-independent B cell responses, and how they are involved in conjugate vaccines as well as autoimmunity of the type seen in celiac disease. You may find it useful to watch now and again later in the course.

About interferons
IFNγ is the only Type II interferon. IFNγ attracts macrophages, and drives their differentiation into M1, for example, and does numerous other things in immunity, including upregulating the expression of MHC on cell surfaces.

Type I IFNs (α and β and some others), which increase cellular resistance to viral infection, can perversely decrease bacterial resistance; this may explain the tendency for bacterial superinfection in, for example, influenza (especially notable in the 1918 Spanish Flu pandemic, where more than 25% of deaths were from secondary bacterial pneumonia). Type I receptors are on all cells. Type III (λ) interferon's receptors are on the mucosal epithelium of small and large bowel.

 

WEEK 5: 27 September 2016

Unit 9: T Cells (PDF)

Unit 10: T Cells (same notes as Unit 9)

Supplemental material (optional): T Cell Supplementary & Review Material
Supplemental material (optional): TCR footprints on MHC

An overall diagram of T cells and their interactions